Searchable abstracts of presentations at key conferences in endocrinology

ea0086oc5.6 | Metabolism, Obesity and Diabetes | SFEBES2022

Labelling and characterisation of somatostatin secreting D-Cells in primary human duodenal organoids culture

Bany Bakar Rula , Sayda Mariwan H. , Smith Christopher A. , Guccio Nunzio , Kay Richard , Gribble Fiona M. , Reimann Frank

Backgrounds and aims: Enteroendocrine cells (EECs) are hormone-secreting cells within the intestinal epithelium that play an important role in regulating food absorption, insulin secretion and appetite. The somatostatin (SST)-producing D-cell is an EEC of particular interest due to the profound inhibition exerted by SST over other EECs, highlighting D-cells as critical regulator of the enteroendocrine axis. The aim of this study was to profile the transcriptom...